반응 #335748

반응 방정식

1,6-dibromobenzene

1,4-dichlorobenzene

tetrahydrofuran

→

1-(6-bromohexyl)-4chlorobenzene

수율 45.0%

용매

toluene

toluene

반응 조건

후처리

1. 1
   온도The full mixture was refluxed for 7 hours
2. 2
   여과The precipitate was then filtered off
3. 3
   기타the phases were separated
4. 4
   세척The organic phase was washed
5. 5
   기타dried
6. 6
   기타evaporated

실험 절차

In the same manner as described in Example 1, a Grignard solution in a mixture containing 450 ml of toluene and 40 ml of tetrahydrofuran was prepared from 58.8 g (0.4 Mol) of 1,4-dichlorobenzene. A solution of 146.4 g (0.6 Mol) of commercially available 1,6-dibromobenzene in 100 ml of toluene and a catalytic amount of dilithium tetrachlorocuprate were added to this solution. The full mixture was refluxed for 7 hours. The precipitate was then filtered off, the filtrate was acidified, and the phases were separated. The organic phase was washed, dried and evaporated, and the residue was fractionated. About 50 g of 1-(6-bromohexyl)-4chlorobenzene (45 percent yield) were obtained at a pressure of 0.2 hPa and at 106° to 109° C.

출처