반응 #335080
ord-bfd6fac7dafe43f0b928d2622cad077d
반응 방정식
methylene chloride
diborane
pyridine
chloroform
sodium bicarbonate
→
amine 10
반응물
시약
없음
반응 조건
상세 조건
See reaction.notes.procedure_details.
실험 절차
An alternative synthesis of 10 can be accomplished by first reacting the amine 6 with a suitable carboxylic acid (as a melt) or with an acid chloride in an inert solvent such as methylene chloride, chloroform, ether or toluene and with a base such as triethylamine, pyridine or sodium bicarbonate present. The intermediate amide is then reduced with a suitable reagent such as diborane in an inert solvent such as ether, tetrahydrofuran (THF), dioxane or dimethoxyethane to afford the desired amine 10.