반응 #334821

반응 방정식

mannitol

acetone

→

1,2:3,4:5,6-Tri-o-isopropylidene-d-mannitol

반응 조건

후처리

1. 1
   농축of concentrated (18M) sulfuric acid as a catalyst for 24 hours in a 2 liter flask
2. 2
   기타the acetone is evaporated by vacuum distillation at about 30° C
3. 3
   workup.ADDITIONThe remaining yellowish oil is diluted with an equal volume of cold water in order
4. 4
   기타to provide the crystalline product
5. 5
   여과The crystals are filtered
6. 6
   기타dried
7. 7
   기타used without further purification

실험 절차

1,2:3,4:5,6-Tri-o-isopropylidene-d-mannitol is prepared by rapidly stirring with a mechanical stirrer, of 40 g of mannitol and 500 ml of anhydrous acetone in the presence of 4.0 ml of concentrated (18M) sulfuric acid as a catalyst for 24 hours in a 2 liter flask. The sulfuric acid is neutralized with about 6.8 g anhydrous sodium carbonate and the acetone is evaporated by vacuum distillation at about 30° C. The remaining yellowish oil is diluted with an equal volume of cold water in order to provide the crystalline product. The crystals are filtered, dried, and used without further purification.

출처