반응 #3347

반응 방정식

benzylbromide

5,5-dimethyl-2,4-dithiohydantoin

→

2-benzylthio-5,5-dimethylimidazolin-4-thione

용매

ethanol

반응 조건

후처리

1. 1
   농축concentrated in vacuo
2. 2
   workup.ADDITIONThe residue was treated
3. 3
   기타purified by column chromatography (CHCl3)
4. 4
   기타Recrystallization from diethyl ether-n-hexane

실험 절차

Initially, 1.91 mL of benzylbromide was added to a solution of 1.6 g of 5,5-dimethyl-2,4-dithiohydantoin in 50 mL of ethanol (EtOH). The reaction mixture was stirred at the room temperature for one hour, and concentrated in vacuo. The residue was treated following the procedure used in Example 62, and purified by column chromatography (CHCl3). Recrystallization from diethyl ether-n-hexane gave 2-benzylthio-5,5-dimethylimidazolin-4-thione in the form of a needle-like crystal. The yield of this compound was 0.87 g with a yield ratio of 34.8%, and the melting point was 133°-134° C.

출처