반응 #334229

반응 방정식

3-methylpiperidine

4-chlorobutyronitrile

→

4-(3-methylpiperidino)-butyronitrile

수율 70.3%

용매

benzene

반응 조건

후처리

1. 1
   기타the precipitate was removed by filtration
2. 2
   기타The residue from the evaporation
3. 3
   workup.DISTILLATIONwas purified by distillation under reduced pressure

실험 절차

In a solution under reflux of 58.6 ml (0.50 mole) of 3-methylpiperidine in 65 ml of benzene, were run in 25 minutes 27.2 g (0.25 mole) of 4-chlorobutyronitrile Reflux was continued for 2h, the precipitate was removed by filtration and the filtrate brought to dryness under reduced pressure. The residue from the evaporation was purified by distillation under reduced pressure to give 29.2 g (yields=70.3%) of 4-(3-methylpiperidino)-butyronitrile which was in the form of a colourless oil. Boiling point 5-6 mmHg =100° C.

출처