반응 #334000

반응 방정식

sodium thiosulfate

title product

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(phenylthio)acetyl]hydrazide

m-chloroperoxybenzoic acid

→

title compound

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(phenylsulfonyl)acetyl]hydrazide

용매

dichloromethane

반응 조건

후처리

1. 1
   workup.WAITAfter about ninety minutes
2. 2
   세척The mixture was washed sequentially with three portions of saturated aqueous sodium bicarbonate and three portions of water
3. 3
   건조The organic phase was dried over sodium sulfate
4. 4
   여과filtered
5. 5
   농축concentrated in vacuo

실험 절차

To a stirred solution of 2.0 g (4.5 mmole) of the title product of Example 2 in 40 ml of cold (ca. 0° ) dichloromethane was added 1.94 g (9.1 mmole) of 81% m-chloroperoxybenzoic acid. After about ninety minutes, 10 ml of saturated aqueous sodium thiosulfate was added. The mixture was washed sequentially with three portions of saturated aqueous sodium bicarbonate and three portions of water. The organic phase was dried over sodium sulfate, filtered, and concentrated in vacuo to give the title compound, m.p. 180°-183°.

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