반응 #332701

반응 방정식

1-benzylamino-butan-2-ol

Intermediate 482

1-benzylamino-butan-2-ol

propylene oxide

→

1-[Benzyl-(2-hydroxy-propyl)-amino]-butan-2-ol

용매

ethanol

반응 조건

후처리

1. 1
   기타After concentration of the mixture under reduced pressure, the residue was purified by column chromatography
2. 2
   기타to give product as an oil

실험 절차

To a solution of 1-benzylamino-butan-2-ol (Intermediate 482, 8.5 g, 47.48 mmol) in ethanol (150 mL) was added propylene oxide (8.8 g, 151 mmole) and the mixture was heated at 150° C. for 2 h in autoclave. After concentration of the mixture under reduced pressure, the residue was purified by column chromatography using methanol in dichloromethane to give product as an oil. Yield: 10.2 g (93%).

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