반응 #332487

반응 방정식

3,4-difluoro-nitrobenzene

morpholine

triethylamine

→

yellow solid

수율 97.0%

3-fluoro-4-morpholinyl nitrobenzene

수율 97.0%

용매

ethyl acetate

반응 조건

후처리

1. 1
   온도while maintaining the temperature below 50° C
2. 2
   추출The mixture was extracted with ethyl acetate
3. 3
   세척washed with brine
4. 4
   건조dried over anhydrous magnesium sulfate
5. 5
   여과filtered
6. 6
   기타dried

실험 절차

3,4-difluoro-nitrobenzene (100 g, 0.63 mol) was added dropwise to morpholine (60 g, 0.69 mol) and triethylamine (70 g, 0.69 mol) in ethyl acetate (300 mL) within 1 hour while maintaining the temperature below 50° C. The mixture is stirred at 45˜50° C. for 10 hours until the completion of the reaction. The mixture was extracted with ethyl acetate, washed with brine and dried over anhydrous magnesium sulfate, filtered, dried, to provide 138 g of yellow solid in 97% yield.

출처