반응 #332

ord-00b95f6f20354bb6923efd18c2b3c116

반응 방정식

Brc1ccccn1
Brc1ccccn1
C1CC2(CCN1)OCCO2
C1CC2(CCN1)OCCO2
→
c1ccc(N2CCC3(CC2)OCCO3)nc1
c1ccc(N2CCC3(CC2)OCC
수율 66.6%

반응물

Brc1ccccn1
Brc1ccccn1
C1CC2(CCN1)OCCO2
C1CC2(CCN1)OCCO2

시약

CC(C)(C)[O-].[Na+]
CC(C)(C)[O-].[Na+]
CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1
CC(C)c1cc(C(C)C)c(-c2ccccc2P(C
CC(=O)O.CC(=O)O.[Pd]
CC(=O)O.CC(=O)O.[Pd]

실험 절차

The same procrdure as EN03653-93-01.

출처

750 AstraZeneca ELN dataset