반응 #3319

반응 방정식

(4-ethylamino-2-phenylamino-pyrimidin-5-yl)methanol

→

4-ethylamino-2-phenylamino-pyrimidine-5-carbaldehyde

수율 99.0%

용매

chloroform

반응 조건

후처리

1. 1
   여과the mixture was filtered through a pad of Celite
2. 2
   세척washing with chloroform
3. 3
   농축The filtrate was concentrated in vacuo

실험 절차

To a solution of (4-ethylamino-2-phenylamino-pyrimidin-5-yl)methanol (173 mg, 0.71 mmol) in 15 mL of chloroform was added manganese oxide (600 mg, 6.89 mmol). After stirring at room temperature overnight, the mixture was filtered through a pad of Celite, washing with chloroform. The filtrate was concentrated in vacuo to give 170 mg (99%) of 4-ethylamino-2-phenylamino-pyrimidine-5-carbaldehyde; mp 155°-157° C.

출처