반응 #3315

반응 방정식

ethylamine

4-chloro-2-methylthio-5-pyrimidinecarboxylate ethyl ester

triethylamine

→

4-ethylamino-2-methylthio-5-pyrimidinecarboxylate ethyl ester

수율 90.0%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   농축concentrated in vacuo
2. 2
   기타partitioned between chloroform and saturated aqueous sodium bicarbonate
3. 3
   건조The organic layer was dried over magnesium sulfate
4. 4
   여과filtered
5. 5
   농축concentrated

실험 절차

To a room temperature solution of 4-chloro-2-methylthio-5-pyrimidinecarboxylate ethyl ester (10.00 g, 43.10 mmol) in 150 mL of tetrahydrofuran was added triethylamine (18.5 mL, 133 mmol) followed by 9 mL of a 70% aqueous solution of ethylamine. The solution was stirred for 30 minutes, then concentrated in vacuo and partitioned between chloroform and saturated aqueous sodium bicarbonate. The organic layer was dried over magnesium sulfate, filtered, and concentrated to provide 9.32 g (90%) of 4-ethylamino-2-methylthio-5-pyrimidinecarboxylate ethyl ester as an oil.

출처