반응 #331462

반응 방정식

2-bromopyridin-3-ol

1-bromo-2-fluoroethane

K2CO3

→

28

수율 68.0%

2-bromo-3-(2-fluoroethoxy)pyridine

수율 68.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도at refluxing for one day until TLC
2. 2
   여과filter
3. 3
   기타dried
4. 4
   농축concentrated
5. 5
   기타The crude product was purified with column chromatography

실험 절차

A mixture of 2-bromopyridin-3-ol 27 (0.1 mmol), 1-bromo-2-fluoroethane (0.2 mmol) and K2CO3 (0.4 mmol) in acetonitrile were stirred at refluxing for one day until TLC indicated that the reaction was complete, and then filter, dried and concentrated under reduce pressure. The crude product was purified with column chromatography to afforded 28 (yield, 68%). 1H NMR (CDCl3): δ 4.25-4.34 (m, 2H), 4.73-4.89 (m, 2H), 7.20-7.22 (m, 2H), 8.01 (s, 1H).

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