반응 #330367

반응 방정식

Methylamine

2-bromo-1,3-difluoro-4-nitrobenzene

DIPEA

→

title compound

수율 91.3%

(2-Bromo-3-fluoro-6-nitrophenyl)methylamine

수율 91.3%

용매

THF

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated in vacuo
2. 2
   기타the residue purified by chromatography
3. 3
   세척eluting with (SiO2 0-80% DCM in cyclohexane)

실험 절차

Methylamine (2M in THF, 19 mL, 38.1 mmol) was added to a solution of 2-bromo-1,3-difluoro-4-nitrobenzene (4.53 g, 19 mmol) and DIPEA (6.8 mL, 38.1 mmol) in THF (70 mL) and the resultant mixture stirred at 60° C. for 3 h. The reaction mixture was concentrated in vacuo and the residue purified by chromatography eluting with (SiO2 0-80% DCM in cyclohexane) to give title compound as an orange/yellow solid (4.32 g, 91%). LCMS (Method C): RT 3.46 min [M+H]+ 249.0, 251.0.

출처