반응 #328989

반응 방정식

hydrazone

2-[(3,4-Dimethoxy-phenyl)-hydrazono]-3-oxo-pentanedioic acid dimethyl ester

cyclohexane

→

dihydropyridazine ester

수율 65.2%

1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid methyl ester

수율 65.2%

용매

dichlorobenzene

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도to reflux in a sealed tube for 4 hours
3. 3
   온도to cool
4. 4
   기타to crystallize the desired product
5. 5
   여과Filtration
6. 6
   기타drying in vacuo

실험 절차

The hydrazone (28) (500 mg) was dissolved in dichlorobenzene and heated to reflux in a sealed tube for 4 hours. The reaction was allowed to cool and cyclohexane was added dropwise to crystallize the desired product. Filtration and drying in vacuo yielded the desired dihydropyridazine ester (29) (295 mg) as a solid. MS+: m/e=307.0 (M+H).

출처