반응 #328917

반응 방정식

2-bromo-1-(4-chloro-phenyl)-ethanone

hydrazine-carbothioic acid O-ethyl ester

→

title product

5-(4-Chloro-phenyl)-3,6-dihydro-[1,3,4]thiadiazin-2-one

용매

acetonitrile

반응 조건

후처리

1. 1
   기타The solid formed
2. 2
   여과is filtered off
3. 3
   세척washed with acetonitrile and ethyl ether
4. 4
   기타dried in vacuo

실험 절차

A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (90.71 mmoles) and hydrazine-carbothioic acid O-ethyl ester (90.71 mmoles) in acetonitrile (84 ml) is stirred at ambient temperature for 3 hours. The solid formed is filtered off, washed with acetonitrile and ethyl ether and then dried in vacuo to yield the title product, which is used directly in the next Step.

출처