반응 #328741

반응 방정식

tert-butyl 3-oxopyrrolidine-1-carboxylate

DMF-DMA

→

tert-Butyl (3Z)-3-[(dimethylamino)methylene]-4-oxopyrrolidine-1-carboxylate

반응 조건

후처리

1. 1
   온도The solution was cooled
2. 2
   기타evaporated under reduced pressure
3. 3
   workup.ADDITIONthe resulting orange solid was treated with hexane (200 mL)
4. 4
   온도cooled in the refrigerator over the weekend
5. 5
   여과The resulting brownish-yellow solid was collected by filtration
6. 6
   기타dried
7. 7
   기타used in the next setp without further purification

실험 절차

A solution of tert-butyl 3-oxopyrrolidine-1-carboxylate (40 g, 216 mmol) was treated with DMF-DMA (267 g, 2241 mmol) and heated at 105° C. for 40 min. The solution was cooled and evaporated under reduced pressure and the resulting orange solid was treated with hexane (200 mL) and cooled in the refrigerator over the weekend. The resulting brownish-yellow solid was collected by filtration, dried and used in the next setp without further purification.

출처