반응 #328730

반응 방정식

1-(tert-butoxylcarbonyl)-3-pyrrolidone

N,N-dimethylformamide dimethyl acetal

→

tert-Butyl 3-[(dimethylamino)methylene]-4-oxopyrrolidine-1-carboxylate

반응 조건

후처리

1. 1
   농축concentrated under reduced pressure
2. 2
   workup.DISSOLUTIONThe residue was redissolved in a minimum amount of dichloromethane
3. 3
   기타triturated with hexane
4. 4
   기타to yield a yellow precipitate

실험 절차

A solution of 1-(tert-butoxylcarbonyl)-3-pyrrolidone (4.10 g) and N,N-dimethylformamide dimethyl acetal (30.0 mL) was heated to 140° C. for 1 h. The resulting mixture was cooled to room temperature and concentrated under reduced pressure. The residue was redissolved in a minimum amount of dichloromethane and triturated with hexane to yield a yellow precipitate. LC-MS=241.1 (M+1).

출처