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4-Fluorophenyl acetylene

1,1,1-tributyl-N,N-dimethylstannanamine

Benzyl azide

→

title compound

1-Benzyl-5-(4-fluorophenyl)-4-(tributylstannyl)-1H-1,2,3-triazole

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후처리

1. 1
   온도The mixture was cooled to ambient temperature
2. 2
   workup.STIRRINGthe vial was stirred unsealed for 10 minutes
3. 3
   온도heated to 130° C. overnight
4. 4
   기타The mixture was purified by silica gel chromatography
5. 5
   세척eluting with a gradient of 5-35% ethyl acetate in hexanes

실험 절차

4-Fluorophenyl acetylene (525 mg, 4.37 mmol) was added to 1,1,1-tributyl-N,N-dimethylstannanamine (1.46 g, 4.37 mmol), and the mixture was stirred in a sealed vial at 50° C. for 2 hours. The mixture was cooled to ambient temperature, and the vial was stirred unsealed for 10 minutes. Benzyl azide (850 μL, 6.80 mmol) was added, and the vial was resealed and heated to 130° C. overnight. The mixture was purified by silica gel chromatography eluting with a gradient of 5-35% ethyl acetate in hexanes to afford the title compound. MS (ESI+) m/z 544.4 (M+H)+.

출처