반응 #327948

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N-Propargylphthalimide

1,1,1-tributyl-N,N-dimethylstannanamine

Benzyl azide

→

title compound

2-((1-Benzyl-4-(tributylstannyl)-1H-1,2,3-triazol-5-yl)methyl)isoindoline-1,3-dione

용매

hexane

반응 조건

후처리

1. 1
   온도The mixture was cooled to ambient temperature
2. 2
   workup.STIRRINGthe vial was stirred unsealed for 10 minutes
3. 3
   온도heated to 130° C. overnight
4. 4
   기타The mixture was purified by silica gel chromatography
5. 5
   세척eluting with a gradient of 10-50% ethyl acetate in hexanes

실험 절차

N-Propargylphthalimide (2.35 g mg, 12.7 mmol) was added to 1,1,1-tributyl-N,N-dimethylstannanamine (4.23 mg, 12.7 mmol) in hexane (3.0 mL) and stirred in a sealed vial at 70° C. for 2 hours. The mixture was cooled to ambient temperature and the vial was stirred unsealed for 10 minutes. Benzyl azide (2.0 mL, 16.0 mmol) was added and the vial was resealed and heated to 130° C. overnight. The mixture was purified by silica gel chromatography eluting with a gradient of 10-50% ethyl acetate in hexanes to afford the title compound. MS (ESI+) m/z 609.3 (M+H)+.

출처