반응 #327713

ord-01df099ea86249c3b2138be726530fce

반응 방정식

Brc1cncc(OCc2ccccc2)c1
3-(Benzyloxy)-5-bromopyridine
CC(C)(C)OC(=O)N1C[C@H]2CNC[C@H]2C1
product
CC(C)(C)OC(=O)N1C[C@H]2CNC[C@H]2C1
(3aR,6aS)-tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
→
CC(C)(C)OC(=O)N1C[C@@H]2CN(c3cncc(OCc4ccccc4)c3)C[C@@H]2C1
title compound
CC(C)(C)OC(=O)N1C[C@@H]2CN(c3cncc(OCc4ccccc4)c3)C[C@@H]2C1
(3aR,6aS)-tert-butyl 5-(5-(benzyloxy)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

반응물

Brc1cncc(OCc2ccccc2)c1
3-(Benzyloxy)-5-bromopyridine
CC(C)(C)OC(=O)N1C[C@H]2CNC[C@H]2C1
product
CC(C)(C)OC(=O)N1C[C@H]2CNC[C@H]2C1
(3aR,6aS)-tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

3-(Benzyloxy)-5-bromopyridine and the product from Example 1C were processed as described in Example 53B to provide the title compound. MS (ESI) m/z 396 (M+H)+.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08648084B2uspto-grants-2014_02