반응 #327712

ord-37088ac12b674121b125fefc5ed5f897

반응 방정식

Brc1cncc(OCc2ccccc2)c1
3-(Benzyloxy)-5-bromopyridine
CC(C)(C)OC(=O)N1C[C@@H]2CCN[C@@H]2C1
(3aS,6aS)-tert-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate
→
CC(C)(C)OC(=O)N1C[C@@H]2CCN(c3cncc(OCc4ccccc4)c3)[C@@H]2C1
title compound
CC(C)(C)OC(=O)N1C[C@@H]2CCN(c3cncc(OCc4ccccc4)c3)[C@@H]2C1
(3aS,6aS)-tert-butyl 1-(5-(benzyloxy)pyridin-3-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

반응물

Brc1cncc(OCc2ccccc2)c1
3-(Benzyloxy)-5-bromopyridine
CC(C)(C)OC(=O)N1C[C@@H]2CCN[C@@H]2C1
(3aS,6aS)-tert-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

3-(Benzyloxy)-5-bromopyridine and (3aS,6aS)-tert-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (prepared as described in WO2001081347) were processed as described in Example 53B to provide the title compound. MS(ESI) m/z 396 (M+H)+.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08648084B2uspto-grants-2014_02