반응 #327362

반응 방정식

3-(1-methyl-1H-indol-5-yl)-phenylamine

DIEA

8-methoxy-3-carboxy-coumarin

HATU

→

product

수율 47.1%

8-Methoxy-2-oxo-2H-chromene-3-carboxylic acid [3-(1-methyl-1H-indol-5-yl)-phenyl]-amide

수율 47.1%

용매

DMF

반응 조건

후처리

1. 1
   기타resulted
2. 2
   기타to react overnight when a solid
3. 3
   기타precipitated out of solution
4. 4
   여과The resulting precipitate was filtered
5. 5
   기타dried under suction, and finally dried overnight in vacuo

실험 절차

DIEA (0.012 mL, 0.071 mmol) was added to 8-methoxy-3-carboxy-coumarin (0.014 g, 0.065 mmol) and HATU (0.027 g, 0.071 mmol) in 0.5 mL of DMF with constant stirring at room temperature until a clear solution resulted. Subsequently, 3-(1-methyl-1H-indol-5-yl)-phenylamine (0.014 g, 0.065 mmol) was added and allowed to react overnight when a solid precipitated out of solution. The resulting precipitate was filtered, dried under suction, and finally dried overnight in vacuo to give 0.013 g of product in 46% yield: LCMS (ESI) m/z 425 (MH+).

출처