반응 #326931

반응 방정식

2-amino-1-methoxypropane

1,3-propane sultone

→

3-(2-methoxy-1-methylethyl)amino-1-propanesulfonic acid

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   온도at reflux for 4 h
2. 2
   여과The solid product was collected by filtration
3. 3
   세척washed with acetone (2×25 mL)
4. 4
   기타dried in a vacuum oven (50° C.)
5. 5
   기타to afford compound EI (3.1 g, 86%)

실험 절차

To a solution of 2-amino-1-methoxypropane (5.0 g, 17.8 mmol) in tetrahydrofuran (25 mL) was slowly added 1,3-propane sultone (2.12 g, 17.0 mmol). The mixture was stirred at reflux for 4 h. The reaction mixture was cooled to room temperature. The solid product was collected by filtration, washed with acetone (2×25 mL), and dried in a vacuum oven (50° C.), to afford compound EI (3.1 g, 86%). 1H NMR (D2O, 500 MHz) δ ppm 3.53 (m, 1H), 3.41 (m, 2H), 3.27 (s, 3H), 3.11 (m, 2H), 2.89 (t, 2H, J=7.3 Hz), 2.00 (m, 2H), 1.18 (d, 3H, J=5.9 Hz). 13C NMR (D2O, 125 MHz) δ ppm 71.73, 58.80, 53.79, 48.08, 43.55, 21.52, 12.79. ES-MS 210 (M−1).

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