반응 #326309

반응 방정식

trimethyloxonium tetrafluoroborate

5-oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester

→

desired product

수율 93.9%

5-Methoxy-2,3,6,7-tetrahydro-(1,4)-diazepine-1-carboxylic acid tert-butyl ester

수율 93.9%

용매

dichlormethane

반응 조건

후처리

1. 1
   세척The reaction was washed with saturated sodium hydrogencarbonate solution and water
2. 2
   기타evaporated

실험 절차

77.5 mg trimethyloxonium tetrafluoroborate was added to 100 mg 5-oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester in 2 mL dichlormethane at 0-5° C. The reaction mixture was stirred over night at RT. The reaction was washed with saturated sodium hydrogencarbonate solution and water and evaporated to yield 100 mg of the desired product. Rt: 0.79 min (method B), (M+H)+: 229

출처