반응 #326181

반응 방정식

4-chloro-6,7-bis (2-methoxyethoxy) quinazoline

3-aminophenyl acetylene

sulphuric acid

→

erlotinib sulphate

용매

water

반응 조건

후처리

1. 1
   온도The reaction mass was heated
2. 2
   기타The solid obtained
3. 3
   여과was filtered
4. 4
   세척washed with ethyl acetate
5. 5
   기타The product was dried at 38-40° C.

실험 절차

1.98 Kg of 4-chloro-6,7-bis (2-methoxyethoxy) quinazoline was suspended in 30 litres of water and 1.0 Kg of 3-aminophenyl acetylene was charged at 25-30° C. Further 0.4 litres sulphuric acid was added. The reaction mass was heated and stirred at 35-40° C. for 1 hour. The solid obtained was filtered and washed with ethyl acetate. The product was dried at 38-40° C. to obtain 2.65 Kg of erlotinib sulphate.

출처