반응 #326176

반응 방정식

4-chloro-6,7-bis(2-methoxyethoxy) quinazoline

3-aminophenyl acetylene

hydrochloric acid

→

erlotinib hydrochloride

수율 84.4%

용매

water

반응 조건

후처리

1. 1
   온도The reaction mass was heated at 35- 40° C. for 1 hour
2. 2
   기타The solid obtained
3. 3
   여과was filtered
4. 4
   세척washed with water
5. 5
   기타The product was dried at 40-45° C.

실험 절차

5.0 g of 4-chloro-6,7-bis(2-methoxyethoxy) quinazoline was suspended in 75 ml of water and 2.55 g of 3-aminophenyl acetylene was added at 25-30° C. followed by 1.0 ml of 50% hydrochloric acid. The reaction mass was heated at 35- 40° C. for 1 hour. The solid obtained was filtered and washed with water. The product was dried at 40-45° C. to obtain 5.8 g of erlotinib hydrochloride.

출처