반응 #326004

반응 방정식

(S)-2-azido-1-phenyl-2,2-bis(3-(trifluoromethoxy)phenyl)ethanol

→

(S)-2-amino-1-phenyl-2,2-bis(3-(trifluoromethoxy)phenyl)ethanol

수율 87.8%

용매

methanol

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered through celite
2. 2
   농축the filtrate was concentrated

실험 절차

A slurry of (S)-2-azido-1-phenyl-2,2-bis(3-(trifluoromethoxy)phenyl)ethanol (64 mg, 0.132 mmol) and 10% Pd on C (40 mg) in methanol (2 mL) was subjected to balloon hydrogenation overnight at rt. The reaction mixture was filtered through celite and the filtrate was concentrated to give (S)-2-amino-1-phenyl-2,2-bis(3-(trifluoromethoxy)phenyl)ethanol as a light yellow oil (53 mg, 87% yield). HPLC: RT=3.40 min (Phenomenex Luna C18 5 u column, eluting with 10-90% MeOH/H2O containing 0.1% phosphoric acid over a 4 minute gradient, monitoring at 220 nm). LCMS: [M+H] 458.1 (Phenomenex Luna C18 column, 4.6×30 mm eluting with 10-90% MeOH/H2O over 2 minutes containing 0.1% TFA; 5 mL/min, monitoring at 220 nm).

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