반응 #3257

반응 방정식

NaNO2

5-cyano-2-hydrazino-4-methylamino-pyrimidine

HCl

→

title compound

수율 96.8%

2-Azido-5-cyano-4-methylamino-pyrimidine

수율 96.8%

용매

water

water

반응 조건

후처리

1. 1
   기타A white precipitate formed
2. 2
   workup.ADDITIONafter the addition
3. 3
   여과The insoluble product was filtered
4. 4
   세척washed with cold water

실험 절차

To a cold (5° C.) solution of 5-cyano-2-hydrazino-4-methylamino-pyrimidine (21.7 g) from Example 4 in a mixture of water (260 mL) and concentrated HCl (26.5 mL) was added dropwise a solution of NaNO2 (10.03 g) in water (25 mL) with overhead mechanical stirring. A white precipitate formed and after the addition was completed, the reaction was stirred for an additional 20 minutes at 5° C. The insoluble product was filtered and washed with cold water to give 22.4 g of the title compound after drying at 23° C. under high vacuum overnight. Crystallization from ethanol provided an analytically pure sample of 2-azido-5-cyano-4-methylamino-pyrimidine; mp 225°-230° C.

출처