반응 #325419

반응 방정식

4-[1-(2-carbamoyl-phenylcarbamoyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester

MeONa

→

product

수율 5.0%

4-[1-(4-oxo-3,4-dihydro-quinazolin-2-yl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester

수율 5.0%

용매

MeOH

반응 조건

후처리

1. 1
   온도to reflux for 6 hr
2. 2
   기타the solvent was removed in vacuo
3. 3
   workup.ADDITIONThe residue was diluted with water
4. 4
   추출extracted with EtOAc (300 mL×3)
5. 5
   건조the organic layer was dried with Na2SO4
6. 6
   농축concentrated
7. 7
   기타purified by column chromatography

실험 절차

A solution of 4-[1-(2-carbamoyl-phenylcarbamoyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester (20 g, 0.05 mmol, crude from the last step) and MeONa (10 g, 0.19 mol) in MeOH (500 mL) was heated to reflux for 6 hr and the solvent was removed in vacuo. The residue was diluted with water and extracted with EtOAc (300 mL×3), the organic layer was dried with Na2SO4, concentrated and purified by column chromatography to afford the product (2 g, 5%).

출처