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7-benzyloxy-4-(4-bromo-2,6-difluoroanilino)-6-methoxyquinazoline

→

4-(4-bromo-2,6-difluoroanilino)-7-hydroxy-6-methoxyquinazoline

수율 98.0%

용매

TFA

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실험 절차

Using an analogous procedure to that described for the synthesis of the starting material in Example 8, 7-benzyloxy-4-(4-bromo-2,6-difluoroanilino)-6-methoxyquinazoline (1.9 g, 4.02 mmol) was reacted with TFA (20 ml) to give 4-(4-bromo-2,6-difluoroanilino)-7-hydroxy-6-methoxyquinazoline (1.5 g, 98%).

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