반응 #324401

반응 방정식

2-[4-(tert-butyldimethylsilyloxy)phenyl]acetic acid

oxalyl dichloride

→

2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타while elevating to room temperature
2. 2
   농축The mixture was concentrated under reduced pressure

실험 절차

Under an argon atmosphere, to a solution of 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetic acid (9) (1.00 g, 3.76 mmol) in CH2Cl2 (10 mL) was added DMF (3 drops) by a Pasteur pipette at room temperature. To this was added oxalyl dichloride (640 μL, 7.56 mmol) at 0° C. and the mixture was stirred for 30 minutes while elevating to room temperature. The mixture was concentrated under reduced pressure to give crude 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride (10) as a colorless oil, which was used in the following reaction without further purification.

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