반응 #324356

반응 방정식

aniline

N,N-diisopropylethylamine

propane sultone

→

di[ethyl(diisopropyl)ammonium] 3-(3-sulfonatopropylanilino)-1-propanesulfonate

수율 94.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   기타The solvent was evaporated
2. 2
   workup.ADDITIONethylacetate was added
3. 3
   여과The precipitated DIPEA bromide was filtered off
4. 4
   기타the filtrate was evaporated
5. 5
   workup.ADDITIONThe residue was treated with ether

실험 절차

A mixture of aniline (7 mmol), N,N-diisopropylethylamine (DIPEA, 18 mmol) and propane sultone (16 mmol) was heated in a pressure tube in 10 mL of acetonitrile at 120-130° C. for 9 h under argon atmosphere. The solvent was evaporated and ethylacetate was added. The precipitated DIPEA bromide was filtered off and the filtrate was evaporated. The residue was treated with ether to give di[ethyl(diisopropyl)ammonium] 3-(3-sulfonatopropylanilino)-1-propanesulfonate as a white or pinky-white solid. Yield: 94%.

출처