반응 #3242

반응 방정식

2-isopropylaminobenzyl alcohol

2,3-dichloro-5,6-dicyano-1,4-benzoquinone

→

2-isopropylaminobenzaldehyde

수율 80.1%

용매

dioxane

반응 조건

후처리

1. 1
   기타The solvent was evaporated
2. 2
   농축the reaction solution was concentrated
3. 3
   workup.ADDITIONmethylene chloride was added
4. 4
   여과followed by filtration
5. 5
   농축The filtrate was concentrated
6. 6
   기타the resulting oily substance was purified by silica gel column chromatography (n-hexane:ethyl acetate=5:1)

실험 절차

To a solution of 9.6 g of 2-isopropylaminobenzyl alcohol in 200 ml of dioxane was added 13.2 g of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in several portions, followed by stirring for an hour. The solvent was evaporated, the reaction solution was concentrated, and methylene chloride was added thereto, followed by filtration. The filtrate was concentrated, and the resulting oily substance was purified by silica gel column chromatography (n-hexane:ethyl acetate=5:1) to give 7.6 g of 2-isopropylaminobenzaldehyde.

출처