반응 #324194

반응 방정식

3,4-dichloroaniline

cycloheptene oxide

HCl

→

trans-3,4-dichloro-N-(2-hydroxycycloheptyl)aniline, hydrochloride salt

반응 조건

후처리

1. 1
   기타The unreacted epoxide is evaporated
2. 2
   workup.ADDITIONthe residue is treated with excess ethereal HCl
3. 3
   기타a syrup results
4. 4
   세척This is washed with ether
5. 5
   기타The residue is crystallized
6. 6
   기타recrystallized from methanol/ether (1/5.5

실험 절차

A solution of 3,4-dichloroaniline, cycloheptene oxide, and concentrated HCl (2 ml.) is heated at reflux temperature for seven (7) days. The unreacted epoxide is evaporated and the residue is treated with excess ethereal HCl, and a syrup results. This is washed with ether. The residue is crystallized and recrystallized from methanol/ether (1/5.5, v/v) to give trans-3,4-dichloro-N-(2-hydroxycycloheptyl)aniline, hydrochloride salt.

출처