반응 #324052

반응 방정식

6-chloro-quinoline-8-carboxylic acid

triethylamine

chloroformic acid methyl ester

water

→

quinoline-8-carboxylic acid amide

용매

acetone

2-(4-methylphenyl)-ethyl-amine

acetone

2-(4-methylphenyl)-ethylamine

반응 조건

후처리

1. 1
   workup.STIRRINGThe whole was stirred for about 10 minutes
2. 2
   workup.STIRRINGthe mixture was again stirred for 1 hour at room temperature
3. 3
   여과the precipitate was filtered off with suction
4. 4
   workup.ADDITIONtreated with a dilute ammonia solution, undissolved matter
5. 5
   여과was filtered off
6. 6
   기타recrystallized from dilute methanol

실험 절차

5.2 g of 6-chloro-quinoline-8-carboxylic acid in 150 ml of acetone were combined, while stirring and cooling with ice, with 2.8 g of triethylamine and 2.6 g of chloroformic acid methyl ester. The whole was stirred for about 10 minutes, a solution of 3.4 g of 2-(4-methylphenyl)-ethylamine in 50 ml of 2-(4-methylphenyl)-ethyl-amine in 50 ml of acetone was added and the mixture was again stirred for 1 hour at room temperature. Then, water was added, the precipitate was filtered off with suction, treated with a dilute ammonia solution, undissolved matter was filtered off and recrystallized from dilute methanol. The 6-chloro-N-(2-<4-methylphenyl>-ethyl)-quinoline-8-carboxylic acid amide so obtained was found to melt at 102°-104° C.

출처