반응 #323675

ord-2925fb08182a40fab31ec394d5cdcec6

반응 방정식

CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCCCCCC)CC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O
N-[N-(3-hexadecanoyloxyoctadecanoyl)-β-alanyl]-L-threonine
N[C@@H](CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1
dibenzyl L-glutamate
→
CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCCCCCC)CC(=O)NCCC(=O)N[C@H](C(=O)N[C@@H](CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1)[C@@H](C)O
dibenzyl N-[N-[N-(3-hexadecanoyloxyoctadecanoyl)-β-alanyl]-L-threonyl]-L-glutamate
수율 38.7%

반응물

CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCCCCCC)CC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O
N-[N-(3-hexadecanoyloxyoctadecanoyl)-β-alanyl]-L-threonine
N[C@@H](CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1
dibenzyl L-glutamate

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Starting from N-[N-(3-hexadecanoyloxyoctadecanoyl)-β-alanyl]-L-threonine (450 mg) prepared by the method of Preparation B-4 and dibenzyl L-glutamate (210 mg), dibenzyl N-[N-[N-(3-hexadecanoyloxyoctadecanoyl)-β-alanyl]-L-threonyl]-L-glutamate (250 mg) was obtained as crystals according to a similar manner to that of Example 2.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04643990uspto-grants-1987_02