반응 #323666

ord-5c1d583b15e34e40b541739538e1000d

반응 방정식

CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCCCCCC)CC(=O)O
3-hexadecanoyloxyoctadecanoic acid
C[C@@H](O)[C@H](NC(=O)CCN)C(=O)O
N-β-alanyl-L-threonine
→
CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCCCCCC)CC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O
N-[N-(3-hexadecanoyloxyoctadecanoyl)-β-alanyl]-L-threonine
수율 48.0%

반응물

CCCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCCCCCC)CC(=O)O
3-hexadecanoyloxyoctadecanoic acid
—
( 5 )
C[C@@H](O)[C@H](NC(=O)CCN)C(=O)O
N-β-alanyl-L-threonine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타prepared by the method

실험 절차

Starting from 3-hexadecanoyloxyoctadecanoic acid (150 mg) prepared by the method described in Preparation A-2 (5) and N-β-alanyl-L-threonine (110 mg), N-[N-(3-hexadecanoyloxyoctadecanoyl)-β-alanyl]-L-threonine (95 mg) was obtained as powder according to similar manner to that of Preparation B-1.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04643990uspto-grants-1987_02