반응 #323112

반응 방정식

hydrochloric acid

calcium hydroxide

sodium carbonate

3,5 dichlorophenol

→

2,6-dichloro-4-hydroxybenzaldehyde

수율 4.5%

용매

chloroform

water

반응 조건

후처리

1. 1
   온도The solution is refluxed for 31/2 hours
2. 2
   workup.DISTILLATIONdistilled the aqueous residue
3. 3
   온도is cooled
4. 4
   여과the solid which separates is filtered
5. 5
   기타Recrystallization from toluene

실험 절차

To a stirred suspension of calcium hydroxide (61 gm), sodium carbonate (69.7 gm), and 3,5 dichlorophenol (20.97 gm) in water (436 ml) at 74° is added chloroform (45.3 gm) over 90 minutes. The solution is refluxed for 31/2 hours. After the slow addition of concentrated hydrochloric acid (170 ml), the acidic solution is steam distilled the aqueous residue is cooled and the solid which separates is filtered. Recrystallization from toluene gives 1.1 gm of 2,6-dichloro-4-hydroxybenzaldehyde.

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