반응 #323069

반응 방정식

water

2-[2-(4-chlorophenyl)-5-(2-furyl)-4-oxazolyl]acetic acid

n-heptyl bromide

triethylamine

→

n-heptyl 2-[2-(4-chlorophenyl)-5-(2-furyl)-4-oxazolyl]acetate

수율 42.8%

용매

dimethylformamide

반응 조건

후처리

1. 1
   기타at room temperature
2. 2
   추출the aqueous mixture is extracted with a mixture of diethyl ether and ethyl acetate (1:1)
3. 3
   workup.ADDITIONThe extract is treated in the same manner

실험 절차

To a solution of 1.5 g of 2-[2-(4-chlorophenyl)-5-(2-furyl)-4-oxazolyl]acetic acid and 1.0 g of n-heptyl bromide in 25 ml of dimethylformamide is dropwise added 0.92 g of triethylamine at room temperature. The mixture is stirred at 30° to 40° C. for 4 hours. Then, the mixture is poured into water, and the aqueous mixture is extracted with a mixture of diethyl ether and ethyl acetate (1:1). The extract is treated in the same manner as described in Example 27, whereby 0.85 g of n-heptyl 2-[2-(4-chlorophenyl)-5-(2-furyl)-4-oxazolyl]acetate is obtained. Yield: 42.7%

출처