반응 #323040

반응 방정식

ethanol

2-furancarboxylic acid

2-amino-7-methoxy-1,8-naphthyridine

→

N-(7-Methoxy-1,8-naphthyridin-2-yl)-2-furancarboxamide

수율 83.7%

용매

water

반응 조건

후처리

1. 1
   workup.DISSOLUTIONis dissolved
2. 2
   기타the crystallised solid is separated by filtration
3. 3
   세척washed with ethanol (2×10 cc)
4. 4
   기타dried at 45° C. under reduced pressure (0.067 kPa)

실험 절차

The procedure is similar to that described in Example 1, but starting with 2-furancarboxylic acid (8.95 g), N,N'-carbonyldiimidazole (12.8 g) and 2-amino-7-methoxy-1,8-naphthyridine (10.5 g). The product produced by precipitation in water (15.5 g; m.p. 199° C.) is dissolved in boiling ethanol (500 cc). After 2 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with ethanol (2×10 cc) and dried at 45° C. under reduced pressure (0.067 kPa). N-(7-Methoxy-1,8-naphthyridin-2-yl)-2-furancarboxamide (13.5 g) is produced, m.p. 201° C.

출처