반응 #322825

반응 방정식

2-(3-bromopropyl)-2H-1,4-benzothiazin-3(4H)-one

sodium cyanide

→

2-(3-cyanopropyl)-2H-1,4-benzothiazin-3(4H)-one

수율 66.8%

용매

water

dimethyl sulfoxide

반응 조건

후처리

1. 1
   여과The resulting crystals were collected by filtration
2. 2
   세척washed with water
3. 3
   기타Recrystallization from methanol

실험 절차

To a solution of 2.86 g of 2-(3-bromopropyl)-2H-1,4-benzothiazin-3(4H)-one in 10 ml of dimethyl sulfoxide was added 0.54 g of sodium cyanide. The mixture was stirred at room temperature for 3 hours and diluted with water. The resulting crystals were collected by filtration and washed with water. Recrystallization from methanol gave 1.55 g (66.7%) of 2-(3-cyanopropyl)-2H-1,4-benzothiazin-3(4H)-one as prisms, m.p. 107°-108° C.

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