반응 #3223

반응 방정식

methyl 2-(tert-butoxycarbonylamino)-4,6-dichloro-5-methoxybenzoate

trifluoroacetic acid

→

title compound

수율 87.0%

Methyl 2-amino-4,6-dichloro-5-methoxybenzoate

수율 87.0%

용매

methylene chloride

반응 조건

후처리

1. 1
   세척The reaction mixture was then washed with saturated aqueous sodium bicarbonate, drie (MgSO4)
2. 2
   여과filtered
3. 3
   농축concentrated

실험 절차

A solution o#methyl 2-(tert-butoxycarbonylamino)-4,6-dichloro-5-methoxybenzoate (2.3 g, 6.6 mM) and trifluoroacetic acid (6.0 g, 53 mM) in methylene chloride (23 mL) was stirred at room temperature for 1.5 hr. The reaction mixture was then washed with saturated aqueous sodium bicarbonate, drie (MgSO4), filtered and concentrated to obtain (87%) the title compound as a yellow oil; MS(CI): 250 (M+H).

출처