반응 #322061

반응 방정식

potassium hydroxide

4-amino-5-formyl-2-methylpyrimidine

2-acetylthiophene

→

2-Methyl-7-(2-thienyl)-pyrido[2,3-d]pyrimidine

수율 17.0%

용매

methanol

반응 조건

후처리

1. 1
   기타was removed After the residue
2. 2
   세척the organic phase was washed with water
3. 3
   기타dried
4. 4
   기타evaporated down

실험 절차

1 ml of 40% strength by weight aqueous potassium hydroxide solution was added to a suspension of 2.0 g (14.6 mmol) of 4-amino-5-formyl-2-methylpyrimidine and 1.93 g. (15.3 mmol) of 2-acetylthiophene in 25 ml of methanol. The reaction mixture was then stirred for 20 hours at 20°-25° C. after which the solvent was removed After the residue had been taken up in dichloromethane, the organic phase was washed with water, dried and evaporated down. Yield: 17%; mp.: 175°-180° C.

출처