반응 #322060

반응 방정식

potassium hydroxide

4-amino-5-formyl-2-methylpyrimidine

4-fluoroacetophenone

→

7-(4-Fluorophenyl)-2-methylpyrido[2,3-d]pyrimidine

수율 50.0%

용매

methanol

반응 조건

후처리

1. 1
   기타a homogeneous solution being formed
2. 2
   기타the solid formed
3. 3
   기타was isolated
4. 4
   기타was recrystallized from ethanol

실험 절차

15 ml of 40% strength by weight aqueous potassium hydroxide solution were slowly added to a suspension of 30.1 g (0.22 mol) of 4-amino-5-formyl-2-methylpyrimidine and 31.7 g (0.23 mol) of 4-fluoroacetophenone in 395 ml of methanol at 20°-25° C., a homogeneous solution being formed. After the mixture had been stirred for 20 hours at about 20° C., the solid formed was isolated and was recrystallized from ethanol. Yield: 50%; mp.>200° C.

출처