반응 #321643

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benzo[b]thiophene-2-boronic acid

N-(5-bromothiophene-2-sulfonyl)pyrrole

→

N-[5-(benzo[b]thien-2-yl)thiophene-2-sulfonyl]pyrrole

수율 68.0%

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후처리

1. 1
   기타Purification by column chromatography

실험 절차

N-[5-(benzo[b]thien-2-yl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner as described in Example 32C from benzo[b]thiophene-2-boronic acid (426 mg, 2.39 mmol) and N-(5-bromothiophene-2-sulfonyl)pyrrole (700 mg, 2.39 mmol). Purification by column chromatography using 2% ethyl acetate/hexanes gave the pure sulfonamide in 68% yield as a brownish-red solid.

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