반응 #3215

반응 방정식

6-iodo-1H-indole-2,3-dione

water

→

title compound

수율 81.8%

7-Iodo-2H-3,1-benzoxazine-2,4(1H)-dione

수율 81.8%

용매

acetic acid

acetic anhydride

반응 조건

후처리

1. 1
   온도while maintaining the temperature of the reaction mixture at 80°-90° C
2. 2
   온도cooled
3. 3
   여과The resulting mixture was filtered
4. 4
   기타the collected solids dried

실험 절차

To a stirred warm (80° C.) solution of 6-iodo-1H-indole-2,3-dione (3.0 g, 11 mM) in acetic acid (10 mL) and acetic anhydride (10 mL) was added in small portions chromium trioxide (1.83 g, 18.3 mM) while maintaining the temperature of the reaction mixture at 80°-90° C. The reaction mixture was then heated at 80° C. for 10 min, cooled and poured into water. The resulting mixture was filtered and the collected solids dried to provide the title compound as a yellow solid (2.6 g, 81.8%); MS(CI): 290 (M+H).

출처