반응 #3210

반응 방정식

water

sodium hydroxide

5-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione

→

title compound

수율 94.0%

Methyl 2-amino-6-methoxybenzoate

수율 94.0%

용매

methanol

반응 조건

후처리

1. 1
   온도cooled to room temperature
2. 2
   추출The resulting solution was extracted with ethyl acetate
3. 3
   기타the combined extracts were dried (Na2 SO4)
4. 4
   여과filtered
5. 5
   농축concentrated

실험 절차

To a stirred solution of sodium hydroxide (0.06 g, 1.5 mM) in methanol (7 mL) under a nitrogen atmosphere was added 5-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione (2.90 g, 15.0 mM). The reaction mixture was stirred at 65° C. for 14.5 hr, cooled to room temperature and poured into water. The resulting solution was extracted with ethyl acetate and the combined extracts were dried (Na2 SO4), filtered and concentrated to provide the title compound (2.55 g, 94%) as a tan oil; MS(CI): 182 (M+H).

출처