반응 #320992

반응 방정식

water

4-chlorophenylisocyanate

2,3-dihydro-5-indenylsulfonamide

sodium hydroxide

→

desired title product

수율 87.4%

N-([(4-chlorophenyl)amino]carbonyl)-2,3-dihydro-1H-indene-5-sulfonamide

수율 87.4%

용매

acetone

acetone

반응 조건

후처리

1. 1
   workup.STIRRINGAfter stirring at room temperature for 18 hours
2. 2
   여과the reaction mixture was filtered
3. 3
   workup.ADDITION490 ml of 1N hydrochloric acid were added to the filtrate
4. 4
   기타thereby providing a fine white precipitate
5. 5
   여과the solid was recovered by filtration

실험 절차

To a solution of 93.2 g of 2,3-dihydro-5-indenylsulfonamide in 300 ml of acetone were added 490 ml of a 1N sodium hydroxide solution. A solution of 79.36 g of 4-chlorophenylisocyanate in 250 ml of acetone was added to the reaction mixture with stirring. After stirring at room temperature for 18 hours, the reaction mixture was filtered and 490 ml of 1N hydrochloric acid were added to the filtrate thereby providing a fine white precipitate. One liter of water was added, and the solid was recovered by filtration to provide 144.86 g of the desired title product, m.p. 169°-172° C.

출처