반응 #320991

반응 방정식

Na2CO3

8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane

1-(2-pyrimidinyl)piperazine

3-chloro-1-cyanopropane

→

4-(2-pyrimidinyl)-1-(3-cyanopropyl)piperazine

용매

n-butanol

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실험 절차

For example, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane is prepared by the condensation of 1-(2-pyrimidinyl)piperazine with 3-chloro-1-cyanopropane by means of Na2CO3 in n-butanol gives 4-(2-pyrimidinyl)-1-(3-cyanopropyl)piperazine which is reduced with LiA1H4 or with H2 and Raney nickel (RaNi) yielding 4-(2-pyrimidinyl)-1-(4-aminobutyl)piperazine, which is finally condensed with 8-oxaspiro[4,5]-decane-7,9-dione(3,3-tetramethyleneglutaric anhydride) in pyridine.

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