반응 #320827

ord-bf2d6c1473544bbb8fe6d305da83802a

반응 방정식

C[C@]12CC[C@H](OCCN)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccoc3)CC[C@]12O
3β-(2-aminoethoxy)-17β-(3-furyl)-5β-androstan-14β-ol
CC1=CC(C)(C(N)=[NH2+])N=N1.O=[N+]([O-])[O-]
3,5-dimethyl-1-pyrazolylformamidinium nitrate
→
C[C@]12CC[C@H](OCCNC(=N)N)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccoc3)CC[C@]12O[N+](=O)[O-]
3β-(2-Guanidinoethoxy)-17β-(3-furyl)-5β-androstan-14β-ol nitrate

반응물

C[C@]12CC[C@H](OCCN)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccoc3)CC[C@]12O
3β-(2-aminoethoxy)-17β-(3-furyl)-5β-androstan-14β-ol
CC1=CC(C)(C(N)=[NH2+])N=N1.O=[N+]([O-])[O-]
3,5-dimethyl-1-pyrazolylformamidinium nitrate

시약

없음

용매

CCO
ethanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    온도at reflux for 7 hrs
  2. 2
    농축the ethanol was concentrated under reduced pressure and 0.18 g of the title compound (I-al)
  3. 3
    기타crystallized as a white solid

실험 절차

To a solution of 0.17 g of 3β-(2-aminoethoxy)-17β-(3-furyl)-5β-androstan-14β-ol (I-aa) in 12 ml of absolute ethanol 0.090 g of 3,5-dimethyl-1-pyrazolylformamidinium nitrate were added and the mixture was kept at reflux for 7 hrs; the ethanol was concentrated under reduced pressure and 0.18 g of the title compound (I-al) crystallized as a white solid.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05593982uspto-grants-1997_01